Our study examines traditional histopathologic features used in predicting DCIS risk with Oncotype DCIS results and how these results affect clinical decision-making at our academic institution. Clinically, these results may be used to assist in selecting which patients with DCIS might safely forgo radiation therapy after breast-conserving surgery however, little is currently published on how this test is being used in practice. The Oncotype DCIS score is a reverse transcription-PCR (RT-PCR)-based assay that was validated to predict which DCIS cases are most likely to recur. Given the increased detection rates of ductal carcinoma in situ ( DCIS) and the limited overall survival benefit from adjuvant breast irradiation after breast-conserving surgery, there is interest in identifying subsets of patients who have low rates of ipsilateral breast tumor recurrence such that they might safely forgo radiation. Lin, Chieh-Yu Mooney, Kelly Choy, Winward Yang, Soo-Ryum Barry-Holson, Keegan Horst, Kathleen Wapnir, Irene Allison, Kimberly Will oncotype DX DCIS testing guide therapy? A single-institution correlation of oncotype DX DCIS results with histopathologic findings and clinical management decisions. Since genomics is not the sole driver of tumor behavior, we will phenotypically characterize DCIS and its Determine whether genetic diversity of DCIS is greater in DCIS with adjacent invasive disease compared to DCIS without. Stains, including quantitative analysis, 7) Identification of upstaged DCIS cases for the radiology aim, 8) Development of image analysis methods for.goals of the project? Aim 1. GENOMIC DIVERSITY AND THE MICROENVIRONMENT AS DRIVERS OF PROGRESSION IN DCIS We have sequenced 500.DNA libraries we plan be able to answer the question of whether DCIS is a clonal disease, and if IDC is an independent disease or is a progression from Body Biopsies are analyzed in two.to DCIS, stroma adjacent to IDC, atypia lesions, Stroma away from disease, normal ductal epithelium and immune infiltrates. Progressing from DCIS to IDC, with the purpose of reducing the need for over treatment for this disease. IDC accounts for 80% of all breast cancers, predominantly affecting women aged 55 and SECURITY CLASSIFICATION OF: U 17.Ductal Carcinoma (IDC), the most common form of breast cancer. Improvements in early diagnosis have led to increased numbers of DCIS cases, however, we presently have no way.ultimately alter the course of treatment for women with a diagnosis of DCIS. Utilizing a unique bank of frozen mammary biopsies, containing samples with DCIS alone, and a combination of DCIS and IDC, we aimĪ precursor to invasive breast cancer. We have initiated the RNA sequencing from these samples and also the DNA sequencing 15. The tissue includes DCIS, IDC.stroma adjacent to DCIS/IDC and normal tissue. A Molecular Framework for Understanding DCISįrozen patient biopsies, these have been annotated by our pathologist and prepared to be taken on for sequencing.
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